Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesis

PTPRD, which encodes the protein tyrosine phosphatase receptor-δ, is one of the most frequently inactivated genes across human cancers, including glioblastoma multiforme (GBM). PTPRD undergoes both deletion and mutation in cancers, with copy number loss comprising the primary mode of inactivation in...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Ortiz, Berenice, Fabius, Armida W. M., Wu, Wei H., Pedraza, Alicia, Brennan, Cameron W., Schultz, Nikolaus, Pitter, Kenneth L., Bromberg, Jacqueline F., Huse, Jason T., Holland, Eric C., Chan, Timothy A.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050622/
https://ncbi.nlm.nih.gov/pubmed/24843164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1401952111
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky