Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesis

PTPRD, which encodes the protein tyrosine phosphatase receptor-δ, is one of the most frequently inactivated genes across human cancers, including glioblastoma multiforme (GBM). PTPRD undergoes both deletion and mutation in cancers, with copy number loss comprising the primary mode of inactivation in...

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Detalhes bibliográficos
Main Authors: Ortiz, Berenice, Fabius, Armida W. M., Wu, Wei H., Pedraza, Alicia, Brennan, Cameron W., Schultz, Nikolaus, Pitter, Kenneth L., Bromberg, Jacqueline F., Huse, Jason T., Holland, Eric C., Chan, Timothy A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050622/
https://ncbi.nlm.nih.gov/pubmed/24843164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1401952111
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