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Inferring fitness landscapes by regression produces biased estimates of epistasis

The genotype–fitness map plays a fundamental role in shaping the dynamics of evolution. However, it is difficult to directly measure a fitness landscape in practice, because the number of possible genotypes is astronomical. One approach is to sample as many genotypes as possible, measure their fitne...

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Detalles Bibliográficos
Main Authors: Otwinowski, Jakub, Plotkin, Joshua B.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2014
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050575/
https://ncbi.nlm.nih.gov/pubmed/24843135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1400849111
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