Cell-State Transitions Regulated by SLUG Are Critical for Tissue Regeneration and Tumor Initiation

Perturbations in stem cell activity and differentiation can lead to developmental defects and cancer. We use an approach involving a quantitative model of cell-state transitions in vitro to gain insights into how SLUG/SNAI2, a key developmental transcription factor, modulates mammary epithelial stem...

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Detalhes bibliográficos
Main Authors: Phillips, Sarah, Prat, Aleix, Sedic, Maja, Proia, Theresa, Wronski, Ania, Mazumdar, Sohini, Skibinski, Adam, Shirley, Stephanie H., Perou, Charles M., Gill, Grace, Gupta, Piyush B., Kuperwasser, Charlotte
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050485/
https://ncbi.nlm.nih.gov/pubmed/24936451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2014.03.008
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