Panaxadiol and Panaxatriol Derivatives as Anti-Hepatitis B Virus Inhibitors

ABSTRACT: 28 Derivatives of panaxadiol (PD) and panaxatriol were synthesized and evaluated for their anti-HBV activity on HepG 2.2.15 cells, of which 17 derivatives inhibited HBV DNA replication. Compounds 4, 9, 10, 14, and 15 showed moderate activity against HBV DNA replication with IC(50) values r...

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Библиографические подробности
Главные авторы: Chen, Hao, Wang, Li-Jun, Ma, Yun-Bao, Huang, Xiao-Yan, Geng, Chang-An, Zhang, Xue-Mei, Chen, Ji-Jun
Формат: Artigo
Язык:Inglês
Опубликовано: Springer Berlin Heidelberg 2014
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050313/
https://ncbi.nlm.nih.gov/pubmed/24955298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13659-014-0018-2
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