Kinetic modeling without accounting for the vascular component impairs the quantification of [(11)C]PBR28 brain PET data

The positron emission tomography radioligand [(11)C]PBR28 targets translocator protein (18 kDa) (TSPO) and is a potential marker of neuroinflammation. [(11)C]PBR28 binding is commonly quantified using a two-tissue compartment model and an arterial input function. Previous studies with [(11)C]-(R)-PK...

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Bibliographic Details
Main Authors: Rizzo, Gaia, Veronese, Mattia, Tonietto, Matteo, Zanotti-Fregonara, Paolo, Turkheimer, Federico E, Bertoldo, Alessandra
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2014
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050251/
https://ncbi.nlm.nih.gov/pubmed/24667911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2014.55
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