Accelerated Methotrexate, Vinblastine, Doxorubicin, and Cisplatin Is Safe, Effective, and Efficient Neoadjuvant Treatment for Muscle-Invasive Bladder Cancer: Results of a Multicenter Phase II Study With Molecular Correlates of Response and Toxicity

PURPOSE: Neoadjuvant cisplatin-based chemotherapy is standard of care for muscle-invasive bladder cancer (MIBC); however, it is infrequently adopted in practice because of concerns regarding toxicity and delay to cystectomy. We hypothesized that three cycles of neoadjuvant accelerated methotrexate,...

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Main Authors: Plimack, Elizabeth R., Hoffman-Censits, Jean H., Viterbo, Rosalia, Trabulsi, Edouard J., Ross, Eric A., Greenberg, Richard E., Chen, David Y.T., Lallas, Costas D., Wong, Yu-Ning, Lin, Jianqing, Kutikov, Alexander, Dotan, Efrat, Brennan, Timothy A., Palma, Norma, Dulaimi, Essel, Mehrazin, Reza, Boorjian, Stephen A., Kelly, William Kevin, Uzzo, Robert G., Hudes, Gary R.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Clinical Oncology 2014
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ORIGINAL REPORTS
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050203/
https://ncbi.nlm.nih.gov/pubmed/24821881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2013.53.2465
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