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Downstream processing of biopharmaceutical proteins produced in plants: The pros and cons of flocculants

All biological platforms for the manufacture of biopharmaceutical proteins produce an initially turbid extract that must be clarified to avoid fouling sensitive media such as chromatography resins. Clarification is more challenging if the feed stream contains large amounts of dispersed particles, be...

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Autors principals: Buyel, Johannes Felix, Fischer, Rainer
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4049906/
https://ncbi.nlm.nih.gov/pubmed/24637706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/bioe.28061
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