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Downstream processing of biopharmaceutical proteins produced in plants: The pros and cons of flocculants

All biological platforms for the manufacture of biopharmaceutical proteins produce an initially turbid extract that must be clarified to avoid fouling sensitive media such as chromatography resins. Clarification is more challenging if the feed stream contains large amounts of dispersed particles, be...

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Detalhes bibliográficos
Main Authors: Buyel, Johannes Felix, Fischer, Rainer
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4049906/
https://ncbi.nlm.nih.gov/pubmed/24637706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/bioe.28061
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