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How and where are nonsense mRNAs degraded in mammalian cells?

The nonsense-mediated mRNA decay (NMD) pathway is responsible for the rapid degradation of eukaryotic mRNAs on which ribosomes fail to terminate translation properly. NMD thereby contributes to the elimination of aberrant mRNAs, improving the fidelity of gene expression, but also serves to regulate...

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Detalhes bibliográficos
Main Authors: Mühlemann, Oliver, Lykke-Andersen, Jens
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4049745/
https://ncbi.nlm.nih.gov/pubmed/20023408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/rna.7.1.10578
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