Fumarate Analogs Act as Allosteric Inhibitors of the Human Mitochondrial NAD(P)(+)-Dependent Malic Enzyme

Human mitochondrial NAD(P)(+)-dependent malic enzyme (m-NAD(P)-ME) is allosterically activated by the four-carbon trans dicarboxylic acid, fumarate. Previous studies have suggested that the dicarboxylic acid in a trans conformation around the carbon-carbon double bond is required for the allosteric...

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Bibliographische Detailangaben
Hauptverfasser: Hsieh, Ju-Yi, Liu, Jyung-Hurng, Yang, Pai-Chun, Lin, Chi-Li, Liu, Guang-Yaw, Hung, Hui-Chih
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4049574/
https://ncbi.nlm.nih.gov/pubmed/24911153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098385
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