Phosphatidylinositol 3-kinase/Akt regulates the balance between plasminogen activator inhibitor-1 and urokinase to promote migration of SKOV-3 ovarian cancer cells

OBJECTIVES: Increased levels of urokinase-type plasminogen activator (uPA) are associated with shortened overall survival in ovarian cancer patients. Additionally, elevated levels of the serine protease inhibitor (serpin), plasminogen activator inhibitor-1 (PAI-1), a uPA inhibitor, have also been co...

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Hlavní autoři: Whitley, Brandi R., Beaulieu, Lea M., Carter, Jennifer C., Church, Frank C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4049274/
https://ncbi.nlm.nih.gov/pubmed/17070899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2006.08.048
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