A Dendritic Cell Vaccine Pulsed with Autologous Hypochlorous Acid-Oxidized Ovarian Cancer Lysate Primes Effective Broad Antitumor Immunity: From Bench to Bedside

PURPOSE: Whole tumor lysates are promising antigen sources for dendritic cell (DC) therapy for they contain many relevant immunogenic epitopes to help prevent tumor escape. Two common methods of tumor lysate preparations are freeze-thaw processing and UVB-irradiation to induce necrosis and apoptosis...

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Detalhes bibliográficos
Main Authors: Chiang, Cheryl Lai-Lai, Kandalaft, Lana E., Tanyi, Janos, Hagemann, Andrea R., Motz, Gregory T., Svoronos, Nikolaos, Montone, Kathleen, Mantia-Smaldone, Gina M., Nisenbaum, Harvey L., Levine, Bruce L., Kalos, Michael, Czerniecki, Brian J., Torigian, Drew A., Powell, Daniel J., Mick, Rosemarie, Smith, Lori, Coukos, George
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4049094/
https://ncbi.nlm.nih.gov/pubmed/23838316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-1185
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