Active involvement of Robo1 and Robo4 in filopodia formation and endothelial cell motility mediated via WASP and other actin nucleation-promoting factors

This study aimed to further elucidate the function of Roundabout proteins in endothelium. We show that both Robo1 and Robo4 are present in human umbilical vein endothelial cells (HUVECs) and have knocked expression down using small interfering RNA (siRNA) technology. Roundabout knockout endothelial...

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Detalhes bibliográficos
Main Authors: Sheldon, Helen, Andre, Maud, Legg, John A., Heal, Paul, Herbert, John M., Sainson, Richard, Sharma, Anshula S., Kitajewski, Jan K., Heath, Victoria L., Bicknell, Roy
Formato: Artigo
Idioma:Inglês
Publicado em: The Federation of American Societies for Experimental Biology 2009
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4048916/
https://ncbi.nlm.nih.gov/pubmed/18948384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.07-098269
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