Radiolabeling and in vitro evaluation of (67)Ga-NOTA-modular nanotransporter – A potential Auger electron emitting EGFR-targeted radiotherapeutic

INTRODUCTION: Modular nanotransporters (MNTs) are vehicles designed to transport drugs from the cell surface via receptor-mediated endocytosis and endosomal escape to nucleus. Hence their conjugation to Auger electron emitters, can cause severe cell killing, by nuclear localization. Herein we evalua...

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Détails bibliographiques
Auteurs principaux: Koumarianou, Eftychia, Slastnikova, Tatiana A., Pruszynski, Marek, Rosenkranz, Andrey A., Vaidyanathan, Ganesan, Sobolev, Alexander S., Zalutsky, Michael R.
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4048709/
https://ncbi.nlm.nih.gov/pubmed/24776093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2014.03.026
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