Evaluation of the Safety and Biodistribution of M032, an Attenuated Herpes Simplex Virus Type 1 Expressing hIL-12, After Intracerebral Administration to Aotus Nonhuman Primates

Herpes simplex virus type 1 (HSV-1) mutants lacking the γ(1)34.5 neurovirulence loci are promising agents for treating malignant glioma. Arming oncolytic HSV-1 to express immunostimulatory genes may potentiate therapeutic efficacy. We have previously demonstrated improved preclinical efficacy, biodi...

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Hlavní autoři: Roth, Justin C., Cassady, Kevin A., Cody, James J., Parker, Jackie N., Price, Kathleen H., Coleman, Jennifer M., Peggins, James O., Noker, Patricia E., Powers, Nicholas W., Grimes, Sheila D., Carroll, Steven L., Gillespie, G. Yancey, Whitley, Richard J., Markert, James M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2014
Témata:
Pre-Clinical Safety Studies
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047998/
https://ncbi.nlm.nih.gov/pubmed/24649838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/humc.2013.201
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