Domain Contributions to Signaling Specificity Differences Between Ras-Guanine Nucleotide Releasing Factor (Ras-GRF) 1 and Ras-GRF2

Ras-GRF1 (GRF1) and Ras-GRF2 (GRF2) constitute a family of similar calcium sensors that regulate synaptic plasticity. They are both guanine exchange factors that contain a very similar set of functional domains, including N-terminal pleckstrin homology, coiled-coil, and calmodulin-binding IQ domains...

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Autores principales: Jin, Shan-Xue, Bartolome, Christopher, Arai, Junko A., Hoffman, Laurel, Uzturk, B. Gizem, Kumar-Singh, Rajendra, Waxham, M. Neal, Feig, Larry A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Neurobiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047421/
https://ncbi.nlm.nih.gov/pubmed/24755227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.557959
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