A Disintegrin and Metalloprotease 17 Dynamic Interaction Sequence, the Sweet Tooth for the Human Interleukin 6 Receptor

A disintegrin and metalloprotease 17 (ADAM17) is a major sheddase involved in the regulation of a wide range of biological processes. Key substrates of ADAM17 are the IL-6 receptor (IL-6R) and TNF-α. The extracellular region of ADAM17 consists of a prodomain, a catalytic domain, a disintegrin domain...

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Main Authors: Düsterhöft, Stefan, Höbel, Katharina, Oldefest, Mirja, Lokau, Juliane, Waetzig, Georg H., Chalaris, Athena, Garbers, Christoph, Scheller, Jürgen, Rose-John, Stefan, Lorenzen, Inken, Grötzinger, Joachim
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047402/
https://ncbi.nlm.nih.gov/pubmed/24790088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.557322
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