3-Hydroxyl-3-methylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitor (Statin)-induced 28-kDa Interleukin-1β Interferes with Mature IL-1β Signaling

Multiple clinical trials have shown that the 3-hydroxyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors known as statins have anti-inflammatory effects. However, the underlying molecular mechanism remains unclear. The proinflammatory cytokine interleukin-1β (IL-1β) is synthesized as a non...

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Detalhes bibliográficos
Main Authors: Davaro, Facundo, Forde, Sorcha D., Garfield, Mark, Jiang, Zhaozhao, Halmen, Kristen, Tamburro, Nelsy Depaula, Kurt-Jones, Evelyn, Fitzgerald, Katherine A., Golenbock, Douglas T., Wang, Donghai
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047391/
https://ncbi.nlm.nih.gov/pubmed/24790079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.571505
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