Galiellalactone Is a Direct Inhibitor of the Transcription Factor STAT3 in Prostate Cancer Cells

The transcription factor STAT3 is constitutively active in several malignancies including castration-resistant prostate cancer and has been identified as a promising therapeutic target. The fungal metabolite galiellalactone, a STAT3 signaling inhibitor, inhibits the growth, both in vitro and in vivo...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Don-Doncow, Nicholas, Escobar, Zilma, Johansson, Martin, Kjellström, Sven, Garcia, Victor, Munoz, Eduardo, Sterner, Olov, Bjartell, Anders, Hellsten, Rebecka
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2014
Aiheet:
Signal Transduction
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047371/
https://ncbi.nlm.nih.gov/pubmed/24755219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.564252
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