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IGFBPrP1 induces liver fibrosis by inducing hepatic stellate cell activation and hepatocyte apoptosis via Smad2/3 signaling

AIM: To investigate the role and mechanism of insulin-like growth factor binding protein-related protein 1 (IGFBPrP1) in the development of liver fibrosis. METHODS: An in vitro model using hepatic stellate cell (HSC)-T6 cells and an in vivo model of rat liver overexpressing IGFBPrP1 were established...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Zhang, Yun, Zhang, Qian-Qian, Guo, Xiao-Hong, Zhang, Hai-Yan, Liu, Li-Xin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Baishideng Publishing Group Inc 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047337/
https://ncbi.nlm.nih.gov/pubmed/24914373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v20.i21.6523
Tagiau: Ychwanegu Tag
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