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IGFBPrP1 induces liver fibrosis by inducing hepatic stellate cell activation and hepatocyte apoptosis via Smad2/3 signaling
AIM: To investigate the role and mechanism of insulin-like growth factor binding protein-related protein 1 (IGFBPrP1) in the development of liver fibrosis. METHODS: An in vitro model using hepatic stellate cell (HSC)-T6 cells and an in vivo model of rat liver overexpressing IGFBPrP1 were established...
Wedi'i Gadw mewn:
Prif Awduron: | , , , , |
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Fformat: | Artigo |
Iaith: | Inglês |
Cyhoeddwyd: |
Baishideng Publishing Group Inc
2014
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Pynciau: | |
Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4047337/ https://ncbi.nlm.nih.gov/pubmed/24914373 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v20.i21.6523 |
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