Phase II Trial of Bortezomib Alone or in Combination with Irinotecan in Patients with Adenocarcinoma of the Gastroesophageal Junction or Stomach

PURPOSE: To determine the effectiveness of bortezomib plus irinotecan and bortezomib alone in patients with advanced gastroesophageal junction (GEJ) and gastric adenocarcinoma. We also sought to explore the effect of these therapeutics on tumor and normal gene expression in vivo. METHODS: Forty-one...

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Hauptverfasser: Ocean, Allyson J., Christos, Paul, Sparano, Joseph A., Shah, Manish A., Yantiss, Rhonda K., Cheng, Jonathan, Lin, Juan, Papetti, Michael, Matulich, Dan, Schnoll-Sussman, Felice, Besanceney-Webler, Christen, Xiang, Jenny, Ward, Maureen, Dilts, Kaili Temple, Keresztes, Roger, Holloway, Shannon, Chen, Eric X., Wright, John J., Lane, Maureen E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047141/
https://ncbi.nlm.nih.gov/pubmed/24526575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-014-0070-0
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