HIF-1α Inhibition Reverses Multidrug Resistance in Colon Cancer Cells via Downregulation of MDR1/P-Glycoprotein

BACKGROUND: Multidrug resistance (MDR) is one of the major reasons chemotherapy-based treatments fail. Hypoxia is generally associated with tumor chemoresistance. However, the correlation between the heterodimeric hypoxia-inducible factor-1 (HIF-1) and the multidrug resistance (MDR1) gene/transporte...

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Main Authors: Chen, Jianfang, Ding, Zhenyu, Peng, Yonghai, Pan, Feng, Li, Jianjun, Zou, Lan, Zhang, Yanling, Liang, Houjie
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047061/
https://ncbi.nlm.nih.gov/pubmed/24901645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098882
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