Expression and significance of hypoxia-inducible factor-1 alpha and MDR1/P-glycoprotein in human colon carcinoma tissue and cells

PURPOSE: Hypoxia in tumors is generally associated with chemoresistance and radioresistance. However, the correlation between the heterodimeric hypoxia-inducible factor-1 (HIF-1) and the multidrug resistance (MDR1) gene/transporter P-glycoprotein (P-gp) has not been clearly investigated. This study...

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Detalhes bibliográficos
Main Authors: Ding, Zhenyu, Yang, Li, Xie, Xiaodong, Xie, Fangwei, Pan, Feng, Li, Jianjun, He, Jianming, Liang, Houjie
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2010
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2944968/
https://ncbi.nlm.nih.gov/pubmed/20217131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00432-010-0828-5
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