Specific mutations in the ligand binding domain selectively abolish the silencing function of human thyroid hormone receptor beta.

Although most nuclear hormone receptors are ligand-dependent transcriptional activators, certain members of this superfamily, such as thyroid hormone receptor (TR) and retinoic acid receptor (RAR), are involved in transcriptional repression. The silencing function of these receptors has been localiz...

Полное описание

Библиографические подробности

Опубликовано в::	Proc Natl Acad Sci U S A
Главные авторы:	Nawaz, Z, Tsai, M J, O'Malley, B W
Формат:	Artigo
Язык:	Inglês
Опубликовано:	National Academy of Sciences 1995
Предметы:	Research Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40468/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8524830/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.25.11691
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