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Specific mutations in the ligand binding domain selectively abolish the silencing function of human thyroid hormone receptor beta.

Although most nuclear hormone receptors are ligand-dependent transcriptional activators, certain members of this superfamily, such as thyroid hormone receptor (TR) and retinoic acid receptor (RAR), are involved in transcriptional repression. The silencing function of these receptors has been localiz...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Nawaz, Z, Tsai, M J, O'Malley, B W
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40468/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8524830/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.25.11691
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