Failure to induce apoptosis via BCL-2 family proteins underlies lack of efficacy of combined MEK and PI3K inhibitors for KRAS mutant lung cancers

Although several groups have demonstrated that concomitant use of MEK and PI3K inhibitors (MEKi/PI3Ki) can induce dramatic tumor regressions in mouse models of KRAS mutant non-small cell lung cancer (NSCLC), ongoing clinical trials investigating this strategy have been underwhelming to date. While e...

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Hauptverfasser: Hata, Aaron N., Yeo, Alan, Faber, Anthony C., Lifshits, Eugene, Chen, Zhao, Cheng, Katherine A., Walton, Zandra, Sarosiek, Kristopher A., Letai, Anthony, Heist, Rebecca S., Mino-Kenudson, Mari, Wong, Kwok-Kin, Engelman, Jeffrey A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046322/
https://ncbi.nlm.nih.gov/pubmed/24675361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-3728
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