Failure to induce apoptosis via BCL-2 family proteins underlies lack of efficacy of combined MEK and PI3K inhibitors for KRAS mutant lung cancers

Although several groups have demonstrated that concomitant use of MEK and PI3K inhibitors (MEKi/PI3Ki) can induce dramatic tumor regressions in mouse models of KRAS mutant non-small cell lung cancer (NSCLC), ongoing clinical trials investigating this strategy have been underwhelming to date. While e...

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Bibliografiset tiedot
Päätekijät: Hata, Aaron N., Yeo, Alan, Faber, Anthony C., Lifshits, Eugene, Chen, Zhao, Cheng, Katherine A., Walton, Zandra, Sarosiek, Kristopher A., Letai, Anthony, Heist, Rebecca S., Mino-Kenudson, Mari, Wong, Kwok-Kin, Engelman, Jeffrey A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2014
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046322/
https://ncbi.nlm.nih.gov/pubmed/24675361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-3728
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