A highly active decarboxylating dehydrogenase with rationally inverted coenzyme specificity.
The isocitrate dehydrogenase of Escherichia coli, which lacks the Rossmann fold common to other dehydrogenases, displays a 7000-fold preference for NADP over NAD (calculated as the ratio of kcat/Km). Guided by x-ray crystal structures and molecular modeling, site-directed mutagenesis has been used t...
Zapisane w:
| Wydane w: | Proc Natl Acad Sci U S A |
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| Główni autorzy: | , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
National Academy of Sciences
1995
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40463/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8524825/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.25.11666 |
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