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Histone deacetylase inhibition facilitates GM-CSF-mediated expansion of myeloid-derived suppressor cells in vitro and in vivo

Chromatin-modifying HDACi exhibit anti-inflammatory properties that reflect their ability to suppress DC function and enhance regulatory T cells. The influence of HDACi on MDSCs, an emerging regulatory leukocyte population that potently inhibits T cell proliferation, has not been examined. Exposure...

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Main Authors: Rosborough, Brian R., Castellaneta, Antonino, Natarajan, Sudha, Thomson, Angus W., Turnquist, Hēth R.
Format: Artigo
Jezik:Inglês
Izdano: Society for Leukocyte Biology 2012
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046249/
https://ncbi.nlm.nih.gov/pubmed/22028329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0311119
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