Structure of the BTB Domain of Keap1 and Its Interaction with the Triterpenoid Antagonist CDDO

The protein Keap1 is central to the regulation of the Nrf2-mediated cytoprotective response, and is increasingly recognized as an important target for therapeutic intervention in a range of diseases involving excessive oxidative stress and inflammation. The BTB domain of Keap1 plays key roles in sen...

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Detalhes bibliográficos
Main Authors: Cleasby, Anne, Yon, Jeff, Day, Philip J., Richardson, Caroline, Tickle, Ian J., Williams, Pamela A., Callahan, James F., Carr, Robin, Concha, Nestor, Kerns, Jeffrey K., Qi, Hongwei, Sweitzer, Thomas, Ward, Paris, Davies, Thomas G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4045772/
https://ncbi.nlm.nih.gov/pubmed/24896564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098896
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