Abnormal Brain Iron Metabolism in Irp2 Deficient Mice Is Associated with Mild Neurological and Behavioral Impairments

Iron Regulatory Protein 2 (Irp2, Ireb2) is a central regulator of cellular iron homeostasis in vertebrates. Two global knockout mouse models have been generated to explore the role of Irp2 in regulating iron metabolism. While both mouse models show that loss of Irp2 results in microcytic anemia and...

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Main Authors: Zumbrennen-Bullough, Kimberly B., Becker, Lore, Garrett, Lillian, Hölter, Sabine M., Calzada-Wack, Julia, Mossbrugger, Ilona, Quintanilla-Fend, Leticia, Racz, Ildiko, Rathkolb, Birgit, Klopstock, Thomas, Wurst, Wolfgang, Zimmer, Andreas, Wolf, Eckhard, Fuchs, Helmut, Gailus-Durner, Valerie, de Angelis, Martin Hrabě, Romney, Steven J., Leibold, Elizabeth A.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4045679/
https://ncbi.nlm.nih.gov/pubmed/24896637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098072
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