The Variable Loop 3 in the Envelope Glycoprotein Is Critical for the Atypical Coreceptor Usage of an HIV-1 Strain

The majority of HIV-1 strains enter CD4(+) T cells using the CCR5 and/or CXCR4 co-receptor. However, we recently identified a transmitted/founder (T/F) virus (ZP6248) that efficiently used an alternative coreceptor GPR15, rather than commonly used CXCR4 and CCR5, to establish clinical infection. To...

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Detalhes bibliográficos
Main Authors: Xiang, Yue, Liu, Wei, Chen, Yue, Zhang, Chuntao, Su, Weiheng, Zhang, Yan, Sun, Jiaxi, Gao, Feng, Jiang, Chunlai
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4045670/
https://ncbi.nlm.nih.gov/pubmed/24897520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098058
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