Age- and Gene-Dosage–Dependent Cre-Induced Abnormalities in the Retinal Pigment Epithelium

To conditionally inactivate genes in the retinal pigment epithelium (RPE) transgenic mouse strains have been developed, in which Cre recombinase (Cre) expression is driven by an RPE-specific gene promoter. The RPE is a quiescent epithelium, and continuous expression of Cre could affect its function....

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Bibliografiske detaljer
Main Authors: He, Lizhi, Marioutina, Mariya, Dunaief, Joshua L., Marneros, Alexander G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2014
Fag:
Short Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4044719/
https://ncbi.nlm.nih.gov/pubmed/24854863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2014.02.007
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