Leptin and the control of pharyngeal patency during sleep in severe obesity

Rationale: Obesity imposes mechanical loads on the upper airway, resulting in flow limitation and obstructive sleep apnea (OSA). In previous animal models, leptin has been considered to serve as a stimulant of ventilation and may prevent respiratory depression during sleep. We hypothesized that vari...

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Hauptverfasser: Shapiro, Steven D., Chin, Chien-Hung, Kirkness, Jason P., McGinley, Brian M., Patil, Susheel P., Polotsky, Vsevolod Y., Biselli, Paolo Jose Cesare, Smith, Philip L., Schneider, Hartmut, Schwartz, Alan R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4044396/
https://ncbi.nlm.nih.gov/pubmed/24557793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00958.2013
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