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The Effect of Zinc and D-Penicillamine in a Stable Human Hepatoma ATP7B Knockout Cell Line

Mutations in the copper (Cu) transporter gene ATP7B, the primary cause of Wilson disease (WD), result in high liver Cu and death of hepatocytes. Cu chelators and zinc salts are the two most important drugs used in the treatment of WD patients; however, the molecular mechanisms of the drugs with rega...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Chandhok, Gursimran, Schmitt, Nadine, Sauer, Vanessa, Aggarwal, Annu, Bhatt, Mohit, Schmidt, Hartmut H. J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4044041/
https://ncbi.nlm.nih.gov/pubmed/24892424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098809
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