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Impact of mTORC1 Inhibition on Keratinocyte Proliferation During Skin Tumor Promotion in Wild-Type and BK5.Akt(WT) Mice

In this study, we examined the impact of rapamycin on mTORC1 signaling during 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced keratinocyte proliferation and skin tumor promotion in both wild-type (FVB/N) and BK5.Akt(WT) mice. TPA activated mTORC1 signaling in a time-dependent manner in cultured p...

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書誌詳細
主要な著者: Rho, Okkyung, Kiguchi, Kaoru, Jiang, Guiyu, DiGiovanni, John
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4043942/
https://ncbi.nlm.nih.gov/pubmed/24114993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.22046
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