Mass Spectrometry Based Identification of Geometric Isomers during Metabolic Stability Study of a New Cytotoxic Sulfonamide Derivatives Supported by Quantitative Structure-Retention Relationships

A set of 15 new sulphonamide derivatives, presenting antitumor activity have been subjected to a metabolic stability study. The results showed that besides products of biotransformation, some additional peaks occurred in chromatograms. Tandem mass spectrometry revealed the same mass and fragmentatio...

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Bibliographic Details
Main Authors: Belka, Mariusz, Hewelt-Belka, Weronika, Sławiński, Jarosław, Bączek, Tomasz
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4043666/
https://ncbi.nlm.nih.gov/pubmed/24893169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098096
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