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Directed Evolution of Human Heavy Chain Variable Domain (V(H)) Using In Vivo Protein Fitness Filter
Human immunoglobulin heavy chain variable domains (V(H)) are promising scaffolds for antigen binding. However, V(H) is an unstable and aggregation-prone protein, hindering its use for therapeutic purposes. To evolve the V(H) domain, we performed in vivo protein solubility selection that linked antib...
में बचाया:
| मुख्य लेखकों: | , , , , , , , |
|---|---|
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Public Library of Science
2014
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4043505/ https://ncbi.nlm.nih.gov/pubmed/24892548 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098178 |
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