Directed Evolution of Human Heavy Chain Variable Domain (V(H)) Using In Vivo Protein Fitness Filter

Human immunoglobulin heavy chain variable domains (V(H)) are promising scaffolds for antigen binding. However, V(H) is an unstable and aggregation-prone protein, hindering its use for therapeutic purposes. To evolve the V(H) domain, we performed in vivo protein solubility selection that linked antib...

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Detalhes bibliográficos
Main Authors: Kim, Dong-Sik, Song, Hyung-Nam, Nam, Hyo Jung, Kim, Sung-Geun, Park, Young-Seoub, Park, Jae-Chan, Woo, Eui-Jeon, Lim, Hyung-Kwon
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4043505/
https://ncbi.nlm.nih.gov/pubmed/24892548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098178
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