Bis-butanediol-mercapturic acid (bis-BDMA) as a urinary biomarker of metabolic activation of butadiene to its ultimate carcinogenic species

Human carcinogen 1,3-butadiene (BD) undergoes metabolic activation to 3,4-epoxy-1-butene (EB), hydroxymethylvinyl ketone (HMVK), 3,4-epoxy-1,2-butanediol (EBD) and 1,2,3,4-diepoxybutane (DEB). Among these, DEB is by far the most genotoxic metabolite and is considered the ultimate carcinogenic specie...

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Detalhes bibliográficos
Main Authors: Kotapati, Srikanth, Sangaraju, Dewakar, Esades, Amanda, Hallberg, Lance, Walker, Vernon E., Swenberg, James A., Tretyakova, Natalia Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Original Manuscript
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4043237/
https://ncbi.nlm.nih.gov/pubmed/24531806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgu047
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