NMR structure and MD simulations of the AAA protease intermembrane space domain indicates peripheral membrane localization within the hexaoligomer

We have determined the solution NMR structure of the intermembrane space domain (IMSD) of the human mitochondrial ATPase associated with various activities (AAA) protease known as AFG3-like protein 2 (AFG3L2). Our structural analysis and molecular dynamics results indicate that the IMSD is periphera...

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Detalhes bibliográficos
Main Authors: Ramelot, Theresa A., Yang, Yunhuang, Sahu, Indra D., Lee, Hsiau-Wei, Xiao, Rong, Lorigan, Gary A., Montelione, Gaetano T., Kennedy, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4043124/
https://ncbi.nlm.nih.gov/pubmed/24055473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2013.09.009
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