pH-Responsive Nanoparticle Vaccines for Dual-Delivery of Antigens and Immunostimulatory Oligonucleotides

Protein subunit vaccines offer important potential advantages over live vaccine vectors, but generally elicit weaker and shorter-lived cellular immune responses. Here we investigate the use of pH-responsive, endosomolytic polymer nanoparticles that were originally developed for RNA delivery as vacci...

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Bibliographic Details
Main Authors: Wilson, John T., Keller, Salka, Manganiello, Matthew J., Cheng, Connie, Lee, Chen-Chang, Opara, Chinonso, Convertine, Anthony, Stayton, Patrick S.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4042837/
https://ncbi.nlm.nih.gov/pubmed/23590591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/nn305466z
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