Human Cathelicidin LL-37 Resistance and Increased Daptomycin MIC in Methicillin-Resistant Staphylococcus aureus Strain USA600 (ST45) Are Associated with Increased Mortality in a Hospital Setting

Bacteremia caused by methicillin-resistant Staphylococcus aureus (MRSA) USA600 has been associated with increased patient mortality. We found that USA600 MRSA exhibited significantly increased resistance to human cathelicidin LL-37 killing and daptomycin MIC creep compared to non-USA600 MRSA. Virule...

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Detalhes bibliográficos
Main Authors: Sakoulas, George, Guram, Kripa, Reyes, Katherine, Nizet, Victor, Zervos, Marcus
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Epidemiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4042812/
https://ncbi.nlm.nih.gov/pubmed/24648548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.00189-14
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