Profiling of rpoB Mutations and MICs for Rifampin and Rifabutin in Mycobacterium tuberculosis

Resistance to rifampin (RIF) and rifabutin (RFB) in Mycobacterium tuberculosis is associated with mutations within an 81-bp region of the rpoB gene (RIF resistance-determining region [RRDR]). Previous studies have shown that certain mutations in this region are more likely to confer high levels of R...

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Bibliographic Details
Main Authors: Jamieson, F. B., Guthrie, J. L., Neemuchwala, A., Lastovetska, O., Melano, R. G., Mehaffy, C.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Mycobacteriology and Aerobic Actinomycetes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4042728/
https://ncbi.nlm.nih.gov/pubmed/24740074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.00691-14
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