T-cell receptor Vβ skewing frequently occurs in refractory cytopenia of childhood and is associated with an expansion of effector cytotoxic T cells: a prospective study by EWOG-MDS

Immunosuppressive therapy (IST), consisting of antithymocyte globulin and cyclosporine A, is effective in refractory cytopenia of childhood (RCC), suggesting that, similar to low-grade myelodysplastic syndromes in adult patients, T lymphocytes are involved in suppressing hematopoiesis in a subset of...

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Autori principali: Aalbers, A M, van den Heuvel-Eibrink, M M, Baumann, I, Beverloo, H B, Driessen, G J, Dworzak, M, Fischer, A, Göhring, G, Hasle, H, Locatelli, F, De Moerloose, B, Noellke, P, Schmugge, M, Stary, J, Yoshimi, A, Zecca, M, Zwaan, C M, van Dongen, J J M, Pieters, R, Niemeyer, C M, van der Velden, V H J, Langerak, A W
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2014
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4042298/
https://ncbi.nlm.nih.gov/pubmed/24786393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2014.28
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