SIRT1 ameliorates age-related senescence of mesenchymal stem cells via modulating telomere shelterin

Mesenchymal stem cells (MSCs) senescence is an age-related process that impairs the capacity for tissue repair and compromises the clinical use of autologous MSCs for tissue regeneration. Here, we describe the effects of SIRT1, a NAD(+)-dependent deacetylase, on age-related MSCs senescence. Knockdow...

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Detalhes bibliográficos
Main Authors: Chen, Huiqiang, Liu, Xianbao, Zhu, Wei, Chen, Han, Hu, Xinyang, Jiang, Zhi, Xu, Yinchuan, Wang, Lihan, Zhou, Yu, Chen, Panpan, Zhang, Na, Hu, Dexing, Zhang, Ling, Wang, Yaping, Xu, Qiyuan, Wu, Rongrong, Yu, Hong, Wang, Jian'an
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4042159/
https://ncbi.nlm.nih.gov/pubmed/24917814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2014.00103
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