Enabling a Genetically Informed Approach to Cancer Medicine: A Retrospective Evaluation of the Impact of Comprehensive Tumor Profiling Using a Targeted Next-Generation Sequencing Panel

BACKGROUND. Oncogenic genetic alterations “drive” neoplastic cell proliferation. Small molecule inhibitors and antibodies are being developed that target an increasing number of these altered gene products. Next-generation sequencing (NGS) is a powerful tool to identify tumor-specific genetic change...

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Détails bibliographiques
Auteurs principaux: Johnson, Douglas B., Dahlman, Kimberly H., Knol, Jared, Gilbert, Jill, Puzanov, Igor, Means-Powell, Julie, Balko, Justin M., Lovly, Christine M., Murphy, Barbara A., Goff, Laura W., Abramson, Vandana G., Crispens, Marta A., Mayer, Ingrid A., Berlin, Jordan D., Horn, Leora, Keedy, Vicki L., Reddy, Nishitha M., Arteaga, Carlos L., Sosman, Jeffrey A., Pao, William
Format: Artigo
Langue:Inglês
Publié: AlphaMed Press 2014
Sujets:
Cancer Diagnostics and Molecular Pathology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041676/
https://ncbi.nlm.nih.gov/pubmed/24797823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2014-0011
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