Enabling a Genetically Informed Approach to Cancer Medicine: A Retrospective Evaluation of the Impact of Comprehensive Tumor Profiling Using a Targeted Next-Generation Sequencing Panel

BACKGROUND. Oncogenic genetic alterations “drive” neoplastic cell proliferation. Small molecule inhibitors and antibodies are being developed that target an increasing number of these altered gene products. Next-generation sequencing (NGS) is a powerful tool to identify tumor-specific genetic change...

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Detalhes bibliográficos
Main Authors: Johnson, Douglas B., Dahlman, Kimberly H., Knol, Jared, Gilbert, Jill, Puzanov, Igor, Means-Powell, Julie, Balko, Justin M., Lovly, Christine M., Murphy, Barbara A., Goff, Laura W., Abramson, Vandana G., Crispens, Marta A., Mayer, Ingrid A., Berlin, Jordan D., Horn, Leora, Keedy, Vicki L., Reddy, Nishitha M., Arteaga, Carlos L., Sosman, Jeffrey A., Pao, William
Formato: Artigo
Idioma:Inglês
Publicado em: AlphaMed Press 2014
Assuntos:
Cancer Diagnostics and Molecular Pathology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041676/
https://ncbi.nlm.nih.gov/pubmed/24797823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2014-0011
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