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Human Cytomegalovirus Replication Is Strictly Inhibited by siRNAs Targeting UL54, UL97 or UL122/123 Gene Transcripts

Human cytomegalovirus (HCMV) causes severe sequelae in immunocompromised hosts. Current antiviral therapies have serious adverse effects, with treatment in many clinical settings problematic, making new therapeutic approaches necessary. We examined the in vitro efficacy of small interfering RNAs (si...

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Détails bibliographiques
Auteurs principaux: Hamilton, Stuart T., Milbradt, Jens, Marschall, Manfred, Rawlinson, William D.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041654/
https://ncbi.nlm.nih.gov/pubmed/24887060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0097231
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