Apolipoprotein E ε4 Does Not Modulate Amyloid-β–Associated Neurodegeneration in Preclinical Alzheimer Disease

BACKGROUND AND PURPOSE: Among cognitively healthy older individuals, the relationship among the 2 hallmark proteins of AD (Aβ and τ APOE ε4) and neurodegeneration is not well-understood. Here, we investigated the relationship between Aβ, p-τ, and APOE ε4 on longitudinal brain atrophy in preclinical...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Desikan, R.S., McEvoy, L.K., Holland, D., Thompson, W.K., Brewer, J.B., Aisen, P.S., Andreassen, O.A., Hyman, B.T., Sperling, R.A., Dale, A.M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Neuroradiology 2013
Pynciau:
Brain
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041629/
https://ncbi.nlm.nih.gov/pubmed/22976236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3174/ajnr.A3267
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